Republican presidential candidate Donald Trump pauses during a meeting with members of the National Border Patrol Council at Trump Tower, Friday, Oct. 7, 2016, in New York. Evan Vucci AP
">

The tape could prove lethal to Trump’s attempt to court women voters, who already prefer Democratic presidential nominee Hillary Clinton by a two to one margin. Trump has employed his daughter, Ivanka, on the campaign trail and embraced family-friendly policies like child care and paid leave.

“This is not more graphic than his radio conversations with Howard Stern, but it’s more recently revealed and therefore likely to have greater impact,” said Republican consultant Whit Ayres. “A great many people are just now paying attention.”

Trump’s supporters have shaken off other controversial statements, but Ayres said the challenge for Trump is moving beyond his base. “He’s not winning right now, therefore just energizing your own supporters isn’t sufficient,” Ayres said. “This is the kind of thing that can make that challenging.”

Republicans in tough re-election bids were looking to distance themselves.

“The comments are inappropriate and completely unacceptable,” North Carolina Sen. Richard Burr said in a statement to McClatchy.

New Hampshire Sen. Kelly Ayotte, a vulnerable Republican incumbent who has struggled with Trump’s candidacy, said Friday his comments were “totally inappropriate and offensive.”

Her opponent, Maggie Hassan, called that response inadequate, demanding that Ayotte disavow Trump.

Trump’s former campaign manager told CNN that the remarks were not “defensible,” but noted it was a private conversation.

“We're electing a leader for the free world, not a Sunday schoolteacher,” Corey Lewandowksi said.

Greg Gordon in Washington contributed to this story.

Lesley Clark: 202-383-6054, @lesleyclark

William Douglas: 202-383-6026, @williamgdouglas